Endothelial Dysfunction In Healthy Passive Smoker

18 Sep 2020, 20:40
Harry Ridwan Dibaca : 342

Endothelial Dysfunction In Healthy Passive Smoker 
Badai Tiksnadi, M. Rizki Akbar, Augustine Purnomowati 
Cardiovascular Department, Padjadjaran University/ Hasan Sadikin General Hospital Bandung

Introduction: The effect of passive smoking on the risk of coronary heart disease is controversial. Since endothelial dysfunction is an early feature of atherogenesis and occurs in young adult who actively smoke cigarettes, passive smoking might also be associated with endothelial damage. 

The objective of this study was to find endothelial dysfunction in passive smokers and  the relationship between intensity and its correlation with duration of exposure to tobacco smoke.

Methods: We studied  80 healthy subjects 20 to 35 years old, which were divided into two groups, consist of 32 passive smokers and 48 subjects as controls. Passive smokers were defined as non-smokers who had been exposed to environmental tobacco smoke for at least one hour daily for three or more years. Endothelial function was measured by response of flow-mediated vasodilation in brachial artery during reactive hyperemia. 

Result: There are no significant differences in baseline characterisics (age, sex and baseline diameter) between two groups. Flow-mediated dilatation response was significantly impaired in the passive smokers 8.7 (2.9) percent vs 12.8 (6.7) percent in control subject, p =0.003. In bivariate analysis, there was a relationship between the intensity of exposure to tobacco smoke and impaired flow-mediated vasodilation (p = 0,043). Upon multivariate analysis, this factor became an independent predictor (B = 1,712; p = 0,023) for impaired flow-mediated vasodilation (model R2 = 0,325; F value = 12,918; p = 0,000). There was no relationship between duration of exposure to tobacco smoke and impairment of dilatation response (p = 0,134) in bivariate analysis, and p = 0,913 in multivariate analysis if data was analyzed within the passive smokers. 

Conclusion: Passive smoking is associated with impairment of endothelium-dependent dilatation, suggesting early event in atherosclerosis. In contrast,there was no correlation between longer duration of exposure to tobacco smoke and severity of impairment.

Pengirim : dr. Badai Tiksnadi