A Relationship Between Level of Plasma Fibrinogen
and Cigarette Smoking in Acute Coronary


18 Sep 2020, 20:44 Harry Ridwan Dibaca : 382


A Relationship Between Level of Plasma Fibrinogen and Cigarette Smoking in Acute Coronary Syndrome Patients: a retrospective study of medical records in Siloam Hospitals Lippo Village 

Vito Damay*, Wahyuni Atmodjo**, Antonia Anna Lukito* * Department of Cardiovascular Medicine, Faculty of Medicine Universitas Pelita Harapan- Heart Center, Siloam Hospitals Lippo Village *Head of Medical Education Unit, Faculty of Medicine-Universitas Pelita Harapan 

ABSTRACT 

Background: Fibrinogen is Factor I essential to blood clotting and have been reported that an elevation of plasma fibrinogen may contribute to the formation of atherosclerotic plaque. A Rupture of atherosclerotic plaque may leads to acute coronary syndrome (ACS). Problems: Although it was postulated that cigarette smoking is a major modifiable risk factor for cardiovascular disease however, the relationship between cigarette smoking and plasma fibrinogen in ACS has not been clearly defined.

Aim: To explore the relationship between cigarette smoking and plasma fibrinogen in patient with ACS, retrospective study of 56 outpatients from medical record at Siloam Hospital Lippo Village Heart Center were observed. Methods: We selected 56 ACS patients with age 40 years old above. They were divided into two groups i.e. smokers group (≥ 10 cigarettes/day and regularly smokes each day for at least previous 3 months) and non-smokers group. The normal - value of fibrinogen level were used as cut-off point. The level of plasma fibrinogen in each group were calculated to get their Mean and SD. To analyze statistically for the differencies between those two groups, student t-test is used with 99% significancy. 

Results: The mean of plasma fibrinogen level in nonsmoker group is under the cut-off of normal value. In contrary, the plasma fibrinogen level in smoker group show an elevation if it is compared to cut- off point of normal value. Moreover,  level of plasma fibrinogen between smokers and non-smokers shows significantly different (P < 0,01).

Conclusion: This study demonstrates a remarkably elevation of plasma fibrinogen level in ACS smoker patients. Supported with previous study, we suggest that an increasing level of fibrinogen have a synergistic effect with the other risk factor of ACS in atherosclerosis process. 

Key words: ACS, plasma fibrinogen, cigarette smoking.

 

Pengirim : Vito Damay

 
 

ARTICLE